Fig. 5: High levels of PDIA1 expression in non-muscle invasive bladder cancer patient tumor tissue predicts a higher risk of recurrence. | Oncogene

Fig. 5: High levels of PDIA1 expression in non-muscle invasive bladder cancer patient tumor tissue predicts a higher risk of recurrence.

From: Protein disulfide isomerase-enriched extracellular vesicles from bladder cancer cells support tumor survival and malignant transformation in the bladder

Fig. 5

A Intensity of BiP (left) and PDIA1 (right) immunofluorescence staining. Each dot represents the average values of a patient. B Representative images of tumor tissue derived from patients with non-recurrent (left) and recurrent (right) NMIBC. PDIA1, BiP, and cell nuclei are respectively stained in green, red, and blue. Scale bars: 40 µm. C Area (left) and fluorescence signal intensity (right) of PDIA1 in BiP negative regions. D Recurrence-free survival rates for patients with corresponding PDIA1 (left) or BiP (right) expression. For (A) and (C), two-tailed Mann-Whitney U tests was performed; n = 42 (non-recurrent) or 63 (recurrent). For (D), patients were categorized into BiP- and PDIA1-high and -low categories based on the corresponding median values. Since there were censored observations, log-rank test was performed. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. BiP binding immunoglobulin protein, PDIA1 protein disulfide isomerase A1, NMIBC non-muscle-invasive bladder cancer, ANOVA analysis of variance.

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