Fig. 7: Association of rare variants of CNR2 with anal polyp occurrences and common and rare variants with monocyte count. | Oncogene

Fig. 7: Association of rare variants of CNR2 with anal polyp occurrences and common and rare variants with monocyte count.

From: Immunomodulatory function of cannabinoid receptor 2 and its agonist osteogenic growth peptide in health and cancer: a study in mice and humans

Fig. 7

a Manhattan plot of p values in the exomic region of CNR2 (build GRCh37) showing common variants (red, MAF > 1%) and rare variants (blue, MAF ≤ 1%) associated with monocyte count. Q63R variants are indicated with a black arrow. b Gene-based burden test of rare variants of CNR2, genes associated with monocyte proliferation (CSF1R and FLT3), and CNR1 for putative loss of function mutations (pLOF) and putative loss of function deleterious missense mutations (DM) at the indicated allele frequencies.

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