Fig. 3: Pathological analysis of livers from hepatic-Erk1R84H transgenic mice reveals tumor development and hepatic abnormalities. | Oncogene

Fig. 3: Pathological analysis of livers from hepatic-Erk1R84H transgenic mice reveals tumor development and hepatic abnormalities.

From: Erk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop

Fig. 3

A Representative H&E staining of liver cross sections from hepatic-homo Erk1R84H mice provided with dox-supplemented diet for 3.7 months (1–2) or 5 months (4–9), or with regular diet for the same periods (3 and 10) (scale bar = 200 µM). B An enlarged view of a liver section from a hepatic-homo mouse expressing Erk1R84H for 5 months, highlighting increased mitotic activity (reflected by chromosomes at various stages of mitosis; circled regions) as a marker of uncontrolled cell proliferation, as is common in HCC (scale bar = 200 µM).

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