Table 5 List of proteins differentially expressed between Day 3 and Day 1, specifically in clones expressing Erk1^R84S and Erk1^R84H (21 are upregulated and 16 are downregulated).

From: Erk1^R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop

Protein ID	Gene name	Erk1^WT Day3 vs Day1		Erk1^R84S Day3 vs Day1		Erk1^R84H Day3 vs Day1
Protein ID	Gene name	FC	P-value	FC	P-value	FC	P-value
Q9QYY8	Spast	0	1	11	0.004363	46	0.000147
Q9D1Q4	Dpm3	−1.1	0.870126	−15	0.000503	31	6.9E−05
Q8R5H6	Wasf1	−2.4	0.11687	21	0.000121	19	0.000162
Q921I2	Klhdc4	1.1	0.840921	6.8	0.015834	19	0.001139
A2ARI4	Lgr4	2.6	0.111842	14	0.00065	16	0.000412
Q80ZK9	Wdtc1	−2	0.290544	28	0.000249	13	0.001842
Q9D0K1	Pex13	1.1	0.819012	4.1	0.03474	13	0.001137
Q9CWP8	Pold4	3.3	0.107246	7.8	0.012328	7.4	0.014237
P23927	Cryab	−1.4	0.360661	3.2	0.005821	6.6	0.000174
B0V2N1	Ptprs	4.1	0.095185	6.2	0.037816	5.8	0.044319
Q60793	Klf4	1.7	0.377421	48	3.58E−05	5.5	0.013268
P40338	Vhl	0	1	−5.9	0.014036	5.4	0.018417
Q78YY6	Dnajc15	3.1	0.135573	18	0.001673	5.1	0.039204
Q8C3S2	Tango6	1	0.974895	8.1	0.005513	5.1	0.021054
P58462	Foxp1	1.6	0.451002	5.8	0.011907	4.1	0.034257
Q6ZPR6	Ibtk	1.3	0.045862	2.1	9.25E−05	3.5	7.26E−07
Q9WVH9	Fbln5	0	1	3.1	0.048228	3.3	0.038753
P18581	Slc7a2	1.8	0.089191	2.3	0.021776	3.1	0.003707
Q9Z0M5	Lipa	1.8	0.004476	2.6	8.37E−05	2.7	6.45E−05
Q9CRA4	Msmo1	1.8	0.001523	2.1	0.00021	2.6	2.63E−05
Q8BGT5	Gpt2	1.4	0.162054	2	0.010143	2.2	0.00578
P10630	Eif4a2	−1.8	0.033419	−2.2	0.005843	−2.1	0.010275
P01942	Hba	1.1	0.542502	−2.2	0.00049	−2.4	0.00026
Q91YK2	Rrp1b	−1.1	0.771838	−2.5	0.012502	−3	0.004568
Q9CQ19	Myl9	−1.3	0.054072	−2.5	1.13E−05	−3	1.54E−06
E9Q414	Apob	−1.1	0.757226	−2.7	0.000272	−3	9.93E−05
Q61838	A2m	−1.2	0.309238	−3.1	1.51E−05	−4.4	1.13E−06
Q3V0B4	Ccdc108	−1.2	0.317086	−3.6	4.49E−06	−5.1	3.67E−07
Q9R0G6	Comp	−1.5	0.527252	−23	0.000682	−5.4	0.028499
Q8VDG6	Mlk4	1.1	0.880009	−5.1	0.016009	−6.7	0.00666
Q8CHT3	Ints5	2.3	0.298635	−12	0.008757	−7.5	0.025675
Q3UGP9	Lrrc58	1.8	0.489965	−7.8	0.032309	−7.9	0.031323
Q8R0W0	Eppk1	2.7	0.119767	12	0.001382	−9.2	0.002986
P60824	Cirbp	−1	0.973381	13	0.001047	−12	0.001281
Q9ES30	C1qtnf3	−1.2	0.795499	−47	8.79E−05	−18	0.000857
P62737;P63268	Acta2;Actg2	−1.5	0.478371	−7.7	0.002748	−22	0.000116
Q64096	Mcf2l	−1.4	0.703606	−40	0.000933	−67	0.000352

FC Fold change.

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Table 5 List of proteins differentially expressed between Day 3 and Day 1, specifically in clones expressing Erk1^R84S and Erk1^R84H (21 are upregulated and 16 are downregulated).

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