Table 6 Phosphorylation sites differentially phosphorylated on both Day 1 and Day 3 in clones expressing Erk1^R84S or Erk1^R84H compared to Erk1^WT.

From: Erk1^R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop

Protein ID	Residue number	Gene name	Day1 Erk1^R84S vs Erk1^WT		Day3 Erk1^R84S vs Erk1^WT		Day1 Erk1^R84H vs Erk1^WT		Day3 Erk1^R84H vs Erk1^WT
Protein ID	Residue number	Gene name	FC	P-value	FC	P-value	FC	P-value	FC	P-value
P58871	1028	Tnks1bp1	760	0.0018	54	0.03482	720	0.0019	92	0.01946
Q99NB9	488	Sf3b1	620	4.6E−05	−43	0.00385	350	0.00011	−43	0.00385
Q9CQS8	13	Sec61b	380	0.00022	71	0.00301	50	0.00535	56	0.00454
Q99P72	98	Rtn4	320	3.9E−05	200	9E−05	1000	6.1E−06	26	0.0045
Q6DID5	105	Mum1	270	0.0013	23	0.04057	41	0.01839	170	0.00245
Q9Z2H5	666	Epb41l1	230	0.00014	32	0.00455	250	0.00011	240	0.00012
P10923	61	Spp1	230	0.00322	49	0.02291	54	0.02021	73	0.01388
P10923	62	Spp1	230	0.00322	49	0.02291	54	0.02021	73	0.01388
P52480	41	Pkm	220	1.5E−05	16	0.00462	460	3.9E−06	51	0.00029
Q68FD5	105	Cltc	200	3.4E−11	150	7.3E−11	210	3E−11	200	3.4E−11
P27361	207	Mapk3	180	0.00913	87	0.02118	590	0.00244	360	0.00428
P97855	231	G3bp1	160	0.00098	49	0.00651	28	0.01591	58	0.00501
P97855	230	G3bp1	160	0.00098	49	0.00651	28	0.01591	58	0.00501
P97855	229	G3bp1	160	0.00289	180	0.00251	28	0.0323	37	0.02199
Q3UVY1	572	Gpr149	74	0.00408	62	0.00535	27	0.01955	17	0.04087
P22518	139	Clk1	68	0.02042	390	0.00254	70	0.01957	61	0.02331
Q6PEE2	18	Ctif	58	0.02343	78	0.01663	660	0.00126	120	0.01005
D3YXK2	366	Safb2	56	7.4E−05	240	3.1E−06	44	0.00013	210	4E−06
D3YXK2	372	Safb2	56	7.4E−05	240	3.1E−06	44	0.00013	210	4E−06
P17182	254	Eno1	53	0.00692	34	0.01357	74	0.00409	370	0.00036
Q9JIK5	387	Ddx21	51	0.00337	23	0.01424	18	0.02174	24	0.01294
Q9CQS8	19	Sec61b	47	0.03061	71	0.01837	50	0.028	56	0.02484
Q3UVY1	517	Gpr149	41	0.00566	19	0.02129	47	0.00449	200	0.00041
P70398	2547	Usp9x	37	0.01272	50	0.00815	63	0.00581	95	0.00309
Q99MD9	648	Nasp	33	0.01824	130	0.00239	19	0.0424	110	0.00308
O55003	85	Bnip3	30	0.00568	290	0.0001	250	0.00013	450	5E−05
Q9D7X1	20	Kctd4	28	0.0047	180	0.00015	200	0.00012	460	2.9E−05
Q8VBV3	124	Exosc2	16	0.03451	26	0.01644	18	0.02995	26	0.01642
Q60605	57	Myl6	8.9	1.8E−05	6.2	0.00011	7	5.6E−05	7	5.8E−05
Q8CE50	40	Snx30	4.3	0.00029	2.3	0.01291	3.9	0.00053	2.7	0.0055
P52927	100	Hmga2	2.9	0.03303	2.9	0.0365	2.7	0.04588	3.8	0.01079
P52927	104	Hmga2	2.9	0.03303	2.9	0.0365	2.7	0.04588	3.8	0.01079
P52927	104	Hmga2	2.6	0.00934	2.6	0.00992	3.8	0.00098	4.5	0.00035
P52927	44	Hmga2	2.3	0.04222	4.1	0.0025	3.3	0.00761	5.9	0.00041
Q9ET54	901	Palld	−2.2	0.01929	−4.8	0.00015	−3.3	0.00166	−9	5.3E−06
Q8K4G5	738	Ablim1	−2.2	0.0203	−2.8	0.00551	−3.8	0.00078	−5.4	9.3E−05
Q8VDP3	777	Mical1	−2.2	0.02564	−2.2	0.02415	−3.1	0.00302	−2.3	0.0216
Q8K4G5	789	Ablim1	−2.4	0.01949	−2.5	0.01312	−5.1	0.00024	−4.7	0.00038
Q01279	695	Egfr	−2.5	0.03173	−5.4	0.00081	−6.9	0.00025	−8.2	0.00011
Q8BRV5	205	Kiaa1671	−2.7	0.00543	−2.2	0.01989	−3.3	0.00134	−2.7	0.00451
Q8K4G5	475	Ablim1	−2.9	0.02284	−3	0.02102	−7.7	0.00029	−8.4	0.0002
O55098	950	Stk10	−2.9	0.00285	−2.9	0.00278	−3.9	0.00047	−4.2	0.00028
P63085	183	Mapk1	−10	0.03017	−370	3.3E−05	−11	0.02407	−1600	3.3E−06
P63085	185	Mapk1	−10	0.03017	−370	3.3E−05	−11	0.02407	−1600	3.3E−06
Q8C4S8	497	Dennd2a	−13	0.0294	−14	0.02476	−13	0.0294	−14	0.02476
Q6DFW0	9		−14	0.02773	−28	0.00812	−14	0.02773	−110	0.00075
Q9R1E0	316	Foxo1	−14	0.02983	−16	0.02557	−14	0.02983	−16	0.02557
P51827	908	Aff3	−18	0.04494	−36	0.01601	−18	0.04494	−36	0.01601
Q69ZW3	719	Ehbp1	−19	0.02342	−78	0.00212	−19	0.02342	−19	0.02173
P30549	341	Tacr2	−22	0.0056	−54	0.00093	−22	0.0056	−54	0.00093
Q99MI1	824	Erc1	−22	0.01711	−43	0.00563	−22	0.01711	−160	0.00067
Q8BI84	1915	Mia3	−23	0.0249	−22	0.0272	−23	0.0249	−22	0.0272
Q8K019	275	Bclaf1	−25	0.03886	−29	0.03163	−140	0.00378	−170	0.00271
P30549	345	Tacr2	−26	0.00484	−54	0.00115	−26	0.00484	−54	0.00115
Q8K4G5	411	Ablim1	−32	0.00093	−160	3E−05	−130	4.6E−05	−160	3E−05
Q80ZK9	513	Wdtc1	−32	0.02052	−23	0.03344	−32	0.02052	−23	0.03344
P25799	452	Nfkb1	−33	0.03057	−200	0.0028	−33	0.03057	−31	0.03329
Q9WTQ5	234	Akap12	−42	0.04107	−53	0.03161	−55	0.03037	−320	0.00397
Q4KMM3	202	Oxr1	−57	0.00371	−440	0.00014	−57	0.00371	−440	0.00014
Q8R1A4	1428	Dock7	−63	0.0036	−360	0.00023	−63	0.0036	−360	0.00023
P97445	2252	Cacna1a	−66	9.9E−11	−94	3.5E−11	−66	9.9E−11	−94	3.5E−11
Q8BVL3	421	Snx17	−68	0.01485	42	0.02752	−510	0.00114	50	0.02178
P23475	518	Xrcc6	−69	4.2E−10	−4.1	0.0001	−69	4.2E−10	−3.9	0.00015
Q6QI06	1176	Rictor	−76	0.00102	−21	0.01102	−19	0.01326	−66	0.00133
Q6QI06	1174	Rictor	−76	0.00102	−21	0.01102	−19	0.01326	−66	0.00133
P97445	2220	Cacna1a	−85	3.2E−11	−160	5.6E−12	−85	3.2E−11	−160	5.6E−12
O35730	324	Ring1	−86	0.0003	17	0.0084	−86	0.0003	17	0.00782
Q91YM2	589	Arhgap35	−87	0.00108	−33	0.00589	−87	0.00108	−32	0.0062
Q8BJ37	132	Tdp1	−89	0.02047	−83	0.02197	−89	0.02047	−640	0.0022
P39447	1576	Tjp1	−120	0.00511	−43	0.02012	−23	0.04597	−43	0.02012
P59222	626	Scarf2	−180	6.3E−06	−89	2.7E−05	−180	6.3E−06	−27	0.00049
Q9ERU9	2342	Ranbp2	−310	0.00419	−100	0.01503	−63	0.02644	−150	0.01009

FC Fold change.

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Table 6 Phosphorylation sites differentially phosphorylated on both Day 1 and Day 3 in clones expressing Erk1^R84S or Erk1^R84H compared to Erk1^WT.

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