Oncogene

Table 7 Phosphorylation sites enriched in cells expressing Erk1^R84S and Erk1^R84H compared to Erk1^WT.

From: Erk1^R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop

Gene name	Residue	Day1 Erk1^R84S vs Erk1^WT		Day3 Erk1^R84S vs Erk1^WT		Day1 Erk1^R84H vs Erk1^WT		Day3 Erk1^R84H vs Erk1^WT		Biogical process
Gene name	Residue	FC	pval	FC	pval	FC	pval	FC	pval	Biogical process
Rtn4	98	320	3.9E−05	200	9.02E−05	1000	6.08E−06	26	0.004503	Apoptosis and autophagy
Tnks1bp1	1028	760	0.001802	54	0.034819	720	0.0019	92	0.019463	Immune response and inflammation
Ctif	18	58	0.02343	78	0.016634	660	0.00126	120	0.010045	Cell cycle regulation and proliferation
MAPK3	207	180	0.009134	87	0.021177	590	0.002442	360	0.004276	Cell cycle regulation and proliferation
Pkm	41	220	1.52E−05	16	0.004618	460	3.88E−06	51	0.000295	Metabolic reprogramming
Sf3b1	488	620	4.57E−05	−43	0.003847	350	0.00011	−43	0.003847	RNA processing and splicing
Bnip3	85	30	0.00568	290	0.000101	250	0.000128	450	5.02E−05	Apoptosis and autophagy
Epb41l1	666	230	0.000137	32	0.004552	250	0.000114	240	0.000122	Cytoskeletal dynamics and cell adhesion
Cltc	105	200	3.42E−11	150	7.27E−11	210	2.96E−11	200	3.38E−11	Cytoskeletal dynamics and cell adhesion
Kctd4	20	28	0.004702	180	0.000145	200	0.000124	460	2.94E−05	Protein transport and signal transduction
Sec61b	13	380	0.000222	71	0.003009	50	0.005346	56	0.004536	Protein transport and signal transduction
Mum1	105	270	0.001302	23	0.040567	41	0.018391	170	0.00245	Chromatin remodeling and transcriptional regulation
Spp1	61	230	0.003225	49	0.022909	54	0.02021	73	0.013878	Immune response and inflammation
Spp1	62	230	0.003225	49	0.022909	54	0.02021	73	0.013878	Immune response and inflammation
Eno1	254	53	0.006923	34	0.013573	74	0.004087	370	0.000361	Metabolic reprogramming
Safb;Safb2	366	56	7.36E−05	240	3.12E−06	44	0.00013	210	4.04E−06	RNA processing and splicing
Safb;Safb2	372	56	7.36E−05	240	3.12E−06	44	0.00013	210	4.04E−06	RNA processing and splicing
Clk1	139	68	0.020415	390	0.002535	70	0.019569	61	0.023313	Chromatin remodeling and transcriptional regulation

FC Fold change.

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