Fig. 8: Gene Ontology analysis for enrichment of gene sets from transcriptomic data reveals the influence of tumor-stroma interactions on biological processes essential to microenvironment signaling, antigen presentation/processing and with DNA replication and damage in DIPG cells. | Oncogene

Fig. 8: Gene Ontology analysis for enrichment of gene sets from transcriptomic data reveals the influence of tumor-stroma interactions on biological processes essential to microenvironment signaling, antigen presentation/processing and with DNA replication and damage in DIPG cells.

From: Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG

Fig. 8

A, B, C Heatmaps and D, E respective network abstraction for A and C (generated using Cytoscape) illustrate differential expression profiles of genes and their association for SU-DIPG-6 and SU-DIPG-13 cells collected from TTA (TEM-6 & TEM-13) and tumor cell only neurospheres (T-6 & T-13). Transcriptomic heatmap and identified network groupings are based on results from gene set enrichment (GSEA) and ingenuity pathway (IPA) analysis: A, D pertain to interferon and Tumor microenvironment signaling [GO: 0051240], B relate to antigen processing and presentation [GO: 0019882], and C, E relate to DNA replication and damage [GO: 0006259].

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