Fig. 6: σ1R inhibition impairs mitochondrial respiration.
From: Integrated control of cancer stemness by σ1 receptor in advanced prostate cancer
A, B Oxygen consumption rate (OCR) and spare respiratory capacity (SRC) in tumor-sphere cells after σ1R knockdown (A) and σ1R antagonist (10 µM) treatment for 24 h (B). OCR and SRC in DU145 cells grown in adherent conditions after σ1R knockdown (C) and σ1R antagonist treatment for 24 h (D). E Oxygen consumption rate (OCR) and spare respiratory capacity (SRC) in DU145 cells grown in adherent conditions and treated with σ1R antagonist for 24 h in glucose-depleted medium. F Proliferation of DU145 cells grown in adherent conditions and treated with σ1R antagonist in complete or glucose-depleted medium. Data are mean ± SD; * P < 0.01 by t-test.
