Fig. 7: METTL16 KD impairs leukemogenesis in an in ovo xenograft model.
From: METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis
A Timeline and design of the CAM assay experiment. B Engraftment of K562 SCR cells on CAM membrane at 9 days of incubation. C Visualization of tumor size of SCR- and shMETTL16-excised organoids at 15 days of incubation (***P < 0.001) (n = 8 for SCR and shMETTL16). D RT-qPCR showing hALU/ckHPRT1 expression in splenic DNA extracted from SCR- and shMETTL16-inoculated chicken embryos (***P < 0.001). Independent-samples t test was used to calculate statistical significance in (C, D).
