Fig. 1
High levels of MKP1 correlate with extended glioblastoma patient survival. a MKP1 mRNA levels were assayed in a set of healthy brain tissues as control (n = 6), glioma cell lines (U87MG, U373MG, U251, A172, and T98), and patient-derived GSC cell lines (GNS166, GNS179, GB2, and GB1). qRT-PCR data are normalized to GAPDH expression. b MKP1 mRNA levels were assayed in a cohort including a set of healthy brain tissue as control (n = 6) and glioma samples (n = 59, 44 of them were GBM). qRT-PCR data are normalized to GAPDH expression and expression in tumors is relative to healthy brain tissue. c Analysis of the correlation of MKP1 expression with different glioma grade samples in two independent cohorts. d Kaplan–Meier curve representing the survival of the GBM patients relative to their MKP1 expression levels (n = 44). e Kaplan–Meier curve representing the survival of the GBM patients relative to their MKP1 expression levels (n = 25)
