Fig. 2: Suppression of MPM cell growth through neutralization of extracellular S100A11.
From: Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma
a Effect of S100A11 recombinant protein on cell growth. Cells were treated or not treated with the foreign S100A11 protein at the indicated concentrations for 48 h. MTT assay was used for the following growth evaluation. b Effect of an anti-S100A11 antibody on the concentration of S100A11 in cell culture media. The antibody was added to the culture media of MPM cells (H2452 and H2052) at time 0. The concentration of S100A11 was significantly lower in the anti-S100A11 antibody-treated group, indicating that the specific antibody can neutralize secreted S100A11. c Effect of neutralization of extracellular S100A11 on cell growth in MPM cells. An anti-S100A11 antibody significantly inhibited cell growth in H2052, H2452, H290, and H28 cells (100 ng/ml antibody for H2052 and H2452 and 1 μg/ml for H290 and H28, respectively)
