Fig. 6: LRIG2 and its downstream mediators are selectively downregulated in endometrial cancer patients. | Oncogenesis

Fig. 6: LRIG2 and its downstream mediators are selectively downregulated in endometrial cancer patients.

From: LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle

Fig. 6

a Box-and-whisker plots present relative mRNA expression levels of LRIG2, LRIG1, and LRIG3 in stage 1A endometrial adenocarcinoma tissues of patients (n = 42) and control endometrial tissues (n = 16). Real-time RT-PCR was performed in triplicates for each specimen, and data were normalized to β-actin. The box plot represents the lower, median, and upper quartiles, and the whiskers represent the 95% confidence interval of the mean. Groups were compared using paired Student’s t-tests, and p values are presented. b ROC curve analyses of LRIG2, LRIG1, and LRIG3 mRNA levels are shown with the AUC values. c Box-and-whisker plots of key mediators of LRIG2 were prepared and shown as described in a

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