Fig. 1: Structure of a representative GST.

The structure of human GSTP1-1 in complex with GSH and the inhibitor NBDHEX is shown (pdb code 3GUS). The N-terminal thioredoxin-like domain is coloured in pink while the all-helical C-terminal domain is coloured in cyan. The G-site is occupied by a GSH molecule while the H-site is occupied by a NBDHEX molecule which are shown in sticks