Fig. 4: Role of GSTP1-1 in JNK signaling pathway. | Oncogenesis

Fig. 4: Role of GSTP1-1 in JNK signaling pathway.

From: Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

Fig. 4

Monomeric GSTP1 protects tumoral cells from apoptosis by inhibition of the JNK signaling pathway through the formation of a GSTP1-JNK-cJun complex that hampers c-Jun phosphorilation. Under stress conditions, GSTP1 may dissociate from the complex and dimerize, thus enabling JNK to phosphorilate c-Jun. This event may also be triggered by the GST inhibitor NBDHEX which binds GSTP1 and induces its release from the complex

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