Fig. 6: GST prodrugs. | Oncogenesis

Fig. 6: GST prodrugs.

From: Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

Fig. 6

a Bioconversion of canfosfamide in an active alkilating metabolite played by GSTP1-1; b synthesis and bioconversion played by GST of a metformin sulfonamide prodrug; c GSH conjugation with nitric oxide releasing agents to form diazeniumdiolate anion and subsequent release of two NO molecules; d Release of active doxorubicin by GST sulfomidase activity played on nitrobenzenesulfonyl analogues

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