Table 1 GST allelic variants associated with cancer risk and other diseases

GSTM1

GSTM1*O

Gene deletion

138350

Uterine leiomyoma, hypertension, oral leukoplakia, prostate cancer, chronic myeloid leukemia, breast cancer, epilepsy

^{35,36,37, 39,40,41, 61}

GSTT1

GSTT1*O

Gene deletion

600436

Uterine leiomyoma, hypertension, oral leukoplakia, brain tumour, breast cancer, coronary heart disease, psoriasis^a, epilepsy

^{35,36,37,38, 40,43, 44}

GSTP1

GSTP1*B

Ile105Val

134660.0002

chronic myeloid leukemia, Parkinson’s disease, Amyotrophic lateral sclerosis

^{39,56, 66}

GSTP1*C

Ile105Val/Ala114Val

134660.0003

Alzheimer’s disease, Parkinson’s disease

^{52, 56}

GSTP1*D

Ala114Val

—

Brain tumour, Parkinson’s disease

^{38, 56}

GSTA1

GSTA1*B

-69(C/T), mutation promoter

138359

Psoriasis^b

⁴⁴

GSTO1

GSTO1*B

Glu155 deletion

605482

Alzheimer’s disease

⁵³

GSTO2

GSTO2*B ^c

Asn142Asp

612314

Breast cancer

⁴²

GSTO2*C ^c

Ala183Gly

—

Spinocerebellar ataxia type 2

⁶⁵