Fig. 6: HER2/NF-κB (p65)/miR-22/HDAC4/p21 and HER2/NF-κB (p65)/miR-22/Ac-p53/p21 signaling circuits contribute to the dual role of miR-22 in resensitizing fulvestrant-resistant breast cancer cells to fulvestrant by transactivation of p21. | Oncogenesis

Fig. 6: HER2/NF-κB (p65)/miR-22/HDAC4/p21 and HER2/NF-κB (p65)/miR-22/Ac-p53/p21 signaling circuits contribute to the dual role of miR-22 in resensitizing fulvestrant-resistant breast cancer cells to fulvestrant by transactivation of p21.

From: A dual role of miR-22 modulated by RelA/p65 in resensitizing fulvestrant-resistant breast cancer cells to fulvestrant by targeting FOXP1 and HDAC4 and constitutive acetylation of p53 at Lys382

Fig. 6

a The HER2/p65 dephosphorylation (ser536) axis negatively modulates miR-22 transcription. b Gain-of-function of miR-22 represses the expression of HDAC4 and FOXP1, which leads to attenuation of the transcription repressor complex63, resulting in a transcriptional activation of p21. c Loss-of-function of miR-22 induces acetylation of p53 at Lys382, resulting in a transactivation of p21

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