Fig. 2: Elevated RecQL4 and AURKB expression in immortalized cell lines.

a Expression level of RecQL4 and AURKB in spontaneous (MCF-10F), SV40-immortalized (RWPE1), and hTERT-immortalized (HMEC-hT1–3 and PHEC-hT) cells relative to their controls. HMEC human normal mammary epithelial cells, PHEC human prostatic epithelial cells. b RecQL4 and AURKB levels in primary and immortalized AG19459 and AG18375 cells determined by Western blotting, and population doublings (PDs) of AG18359 and AG18375 cells infected with hTERT retrovirus only, and AG18375 cells infected with both hTERT and Flag-RecQL4 retrovirus