Table 1 Tpl2 −/− primary keratinocytes infected with v-rasHa undergo malignant conversion in response to fibroblast signals
Condition | Foci | Ratio of conversion | Significance |
|---|---|---|---|
WT Ker Ras | 0 | 0/5 | |
WT Ker Ras in WT FCM | 3 | 3/5 | NS |
WT Ker Ras in KO FCM | 2 | 2/5 | NS |
KO Ker Ras | 0 | 0/6 | |
KO Ker Ras in WT FCM | 5 | 5/6 | P < 0.005 (vs. KO Ker Ras) |
KO Ker Ras in KO FCM | 7 | 7/6 | P < 0.00001 (vs. KO Ker Ras) |
