Fig. 8: CDCA5 knockdown suppresses activation of ERK signaling pathway.

a Protein levels of p-ERK, ERK, and c-jun in HCT116 cells after transduction with shRNA-CDCA5 or sh-Ctrl lentiviurs, as determined by Western-blot analysis. b The integrated band density was determined using ImageLab Software, using GAPDH as the internal control. Gene expression is presented as the percentage relative to the sh-Ctrl group (*P < 0.05). All experiments were performed in triplicate