Fig. 2: Restoration of p53 in orthotopically transplanted lung adenocarcinomas causes an infiltration of CD45pos. immune cells and fibroblasts and elevated chemokine levels.
From: Natural killer cells limit the clearance of senescent lung adenocarcinoma cells
a Histological sections from Control and p53-Restored tumors at Day 2, 6, and Day 10. H&E and IHC for GFP, CD45, and SMA. b Multiparameter cytokine detection in bronchioalveolar lavage (BAL) of Control and p53-Restored mice. Significantly changing cytokines as determined by t-test are indicated (IL-6, CCL2, CXCL1, M-CSF, and CCL4). c Multiparameter cytokine detection in KPrLG cell culture supernatant after p53 restoration in vitro
