Fig. 5: NK cells limit a p53-mediated immunoinflammatory reaction that is associated with lung adenocarcinoma regression.

Cell suspensions from the lungs of KPr tumor-bearing Rag1^-/- mice treated with corn oil (Control), tamoxifen (Restored), and tamoxifen, and anti-NK1.1 (Restored NK Depleted) were subjected to multiparameter flow cytometry. a Cells gated to include live singlets that are CD45^pos. are plotted on CD11b X F4/80. b Alveolar macrophages (CD11b^neg.; F4/80^pos.) are quantified from a. c Interstitial macrophages (CD11b^pos.;F4/80^pos.) are quantified from a. d CD11b^pos. cells from a are plotted on Ly6G X Ly6C. e Monocytes (CD11b^pos.; Ly6C^pos.; Ly6G^neg.) are quantified from d. f Neutrophils (CD11b^pos.; Ly6C^pos.; Ly6G^pos.) are quantified from d. Analysis of significance between control and restored treatment groups was performed by t-test