Fig. 2: Differential expression microarray analysis of OVCAR3 controls, OVCAR3 BORIS KD, and OVCAR3 BORIS KO. | Oncogenesis

Fig. 2: Differential expression microarray analysis of OVCAR3 controls, OVCAR3 BORIS KD, and OVCAR3 BORIS KO.

From: The epigenetic factor BORIS (CTCFL) controls the androgen receptor regulatory network in ovarian cancer

Fig. 2

a Volcano plots depicting differentially expressed genes in BORIS KD vs control cells and BORIS KO vs control cells. Selected differentially expressed genes are shown in colored circles (|fold change| ≥ 1.9 and FDR-adjusted p-value < 0.1). b The number of differentially expressed genes (overexpressed and underexpressed) identified in BORIS KD and BORIS KO cells. c Pie chart depicting the percentage of overexpressed and underexpressed genes in BORIS KD and KO cells. d Heatmap showing the top 20 genes that changed expression (Z-score) upon BORIS depletion (KD and KO). e Venn diagram showing the number of differentially expressed genes found in BORIS KD-only (yellow), BORIS KO-only (blue), and both BORIS KD and KO cells (green). KD knockdown, KO knockout

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