Fig. 6: Schematic model of AR transcriptional repression mediated by BORIS and its clinical relevance in ovarian cancer patients.

a BORIS is recruited to the AR gene promoter and mediates its transcriptional repression in OVCAR3 cell line. The AR levels reduction and the endogenous presence of BORIS have an effect in the FN1, CD97, and FAM129A gene repression. In contrast, in BORIS KO and KD cells, the absence of BORIS allows the AR gene activation, which could increase the transcript levels of FN1, CD97, and FAM129A. b A subset of SOC patients show high levels of BORIS, which is associated with malignancy in contrast to BOC and non neoplastic patients which have low levels of BORIS. OC ovarian cancer, BOC borderline ovarian cancer, SOC serous ovarian cancer, KO knockout, KD knockdown