Fig. 1: Protein phosphatase 2A (PP2A) heterotrimeric holoenzymes. | Oncogenesis

Fig. 1: Protein phosphatase 2A (PP2A) heterotrimeric holoenzymes.

From: PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells

Fig. 1

One scaffold (PR65 or A) subunit binds to one catalytic (C) subunit to form an A/C heterodimer, which can further complex with one of the regulatory (B) subunits. The A and C subunits each contain two highly conserved isoforms (97% similarity between Cα and Cβ and 87% similarity between Aα and Aβ). A large number of the B subunits are classified into four distinct subfamilies (B, B′, B″, and B‴), which share no homology1,2,3

Back to article page