Fig. 7: Proposed model for the role of CXCL5 in gastric cancer metastasis. | Oncogenesis

Fig. 7: Proposed model for the role of CXCL5 in gastric cancer metastasis.

From: CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils

Fig. 7

High level of CXCL5 in tumor microenvironment promotes GC metastasis by enhancing GC cell migration and invasion through the induction of EMT. CXCL5 exerts these effects by two mechanisms: (1) CXCL5 directly activates ERK signaling pathway in GC cells to upregulate Snail expression; (2) CXCL5 induces pro-tumor activation of neutrophils via ERK and p38 signaling pathways, which leads to the release of increased levels of inflammatory factors (e.g, IL-6 and IL-23), subsequently enhancing the metastatic potential of gastric cancer cells.

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