Fig. 4: MTHFR promotes GC cell proliferation. | Oncogenesis

Fig. 4: MTHFR promotes GC cell proliferation.

From: MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine

Fig. 4

a MTT assay of cell proliferation at 24, 48, and 72 h after transfection with MTHFR siRNAs. b Flow cytometry of cell cycle, visualized by PI staining. c Cell apoptosis by flow cytometry, visualized using Annexin-V/PI staining. d Colony formation assay 14 days after transfection. e Effect of MTHFR knockdown on cell cycle-related proteins. All the results are shown as mean±SD. n = 3, *p < 0.05, **p < 0.01, Student’s t test.

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