Fig. 5: Overexpression of MeCP2, MTHFD2, and MTHFR rescues miR-22-induced cellular phenotypes in GC cells. | Oncogenesis

Fig. 5: Overexpression of MeCP2, MTHFD2, and MTHFR rescues miR-22-induced cellular phenotypes in GC cells.

From: MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine

Fig. 5

a MTT assay of cell proliferation in AGS and MKN45 cells co-transfected with MeCP2 and miR-22. b Cell proliferation in AGS and MKN45 cells co-transfected with MTHFD2 and miR-22. c Cell proliferation in AGS and MKN45 cells co-transfected with MTHFR and miR-22. All the results are shown as the mean±SD. n = 3, *p < 0.05, **p < 0.01, Student’s t test. d Expression CDK4, P21, P16, and MeCP2 in cells co-transfected with MeCP2 and miR-22. e Expression CDK4, P21, P16, and MeCP2 in cells co-transfected with MTHFD2 and miR-22. f Expression CDK4, P21, P16, and MeCP2 in cells co-transfected with MTHFR and miR-22.

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