Fig. 3: Mixed tumors (10% U87EGFRvIII, 90% U87EGFRwt) show increased infiltrative properties in vivo. | Oncogenesis

Fig. 3: Mixed tumors (10% U87EGFRvIII, 90% U87EGFRwt) show increased infiltrative properties in vivo.

From: Dissecting the role of crosstalk between glioblastoma subpopulations in tumor cell spreading

Fig. 3

a mCherry-labeled U87EGFRwt cells were co-injected intracranially with unlabeled U87EGFRvIII cells (U87vIII), in ratio of 9:1 (or only U87EGFRwt cells as control), into the NSG mice striatum. Three days later the mice were euthanized and brains were imaged under a fluorescent dissecting microscope. b, c Index of % of the cell dispersion was calculated (c) comparing the sum intensity from the primary tumor to the dispersed cells in the brain as indicated in (b). *P = 0.01, n = 6 mice per each group. Values are standard error (SE).

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