Fig. 3: GLUT1 promotes growth and metastasis in vivo. | Oncogenesis

Fig. 3: GLUT1 promotes growth and metastasis in vivo.

From: Dysregulation of the miR-148a–GLUT1 axis promotes the progression and chemoresistance of human intrahepatic cholangiocarcinoma

Fig. 3

a GLUT1 upregulation enhanced RBE cell xenograft tumor growth in nude mice, while GLUT1 knockdown reduced HuCCT1 growth. b The expression of MMP2 and cyclin D1 was evaluated using western blot assays with xenograft tissues. c IHC staining was used to detect Ki-67 expression in xenograft tissues. d Representative bioluminescence images, gross specimens, and hematoxylin and eosin (H&E) staining of the lung tumors are shown in the left panels. The number and incidence of nodules are displayed in the right panels. Bar = 100 μm. Data are means ± SD of three independent experiments. **P < 0.01; ***P < 0.001.

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