Fig. 4: GLUT1 inhibition sensitizes iCCA cells to gemcitabine in vitro and in vivo. | Oncogenesis

Fig. 4: GLUT1 inhibition sensitizes iCCA cells to gemcitabine in vitro and in vivo.

From: Dysregulation of the miR-148a–GLUT1 axis promotes the progression and chemoresistance of human intrahepatic cholangiocarcinoma

Fig. 4

a Administration of gemcitabine induced the expression of GLUT1 in HuCCT1 cells in a dose-dependent manner. b CCK8 analyses show cell viability in gemcitabine-treated HuCCT1 cells with or without GLUT1 knockdown. c Flow cytometric analyses show cell apoptosis in gemcitabine-treated HuCCT1 cells with or without GLUT1 knockdown. d Western blot assays show the expression of cleaved caspase-3 and cleaved PARP in gemcitabine-treated HuCCT1 cells with or without GLUT1 knockdown. e GLUT1 knockdown increased the sensitivity of gemcitabine in vivo. Data are means ± SD of three independent experiments. **P < 0.01; ***P < 0.001.

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