Fig. 6: MiR-148a inhibits iCCA growth and metastasis by targeting GLUT1. | Oncogenesis

Fig. 6: MiR-148a inhibits iCCA growth and metastasis by targeting GLUT1.

From: Dysregulation of the miR-148a–GLUT1 axis promotes the progression and chemoresistance of human intrahepatic cholangiocarcinoma

Fig. 6

a Migration and invasion assays were performed on HuCCT1 cells transfected with a negative control, miR-148a, miR-148a plus con, or miR-148a plus GLUT1. Bar = 100 μm. b MiR-148a overexpression or silencing decreased or increased GLUT1 protein levels in the indicated cells. c In vivo subcutaneous tumor growth assay of the indicated cells injected subcutaneously into the flanks of nude mice. Representative images and tumor volumes are shown. d In vivo metastasis assay of the indicated cells injected via the tail veins into nude mice. Data are means ± SD of three independent experiments. Bar = 100 μm. **P < 0.01; ***P < 0.001.

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