Fig. 7: Carbidopa inhibits PCa in nude mice. | Oncogenesis

Fig. 7: Carbidopa inhibits PCa in nude mice.

From: Carbidopa suppresses prostate cancer via aryl hydrocarbon receptor-mediated ubiquitination and degradation of androgen receptor

Fig. 7

a Measurement of tumor volumes at indicated time points, following implantation of LNCaP cells in BALB/c nude mice. The nude mice were treated with 7.5 mg/kg and equal volume of vehicle. Data are given as means ± SEM, n = 6. **p < 0.01 versus control. b Measurement of harvested tumor weights at the conclusion of the study. Data are given as means ± SEM, n = 6. **p < 0.01 versus control. c Photographs of resected tumor tissues from BALB/c nude mice at the conclusion of the study. d Measurement of body weights at the conclusion of the study. Data are given as means ± SEM, n = 6. e Immunohistochemically staining of tumor specimens for cell proliferation marker Ki67. Immunoreactivity was detected by DAB chromogen (brown). Scale bars = 100 μm. f TUNEL assay in tumor specimens. Apoptotic cells were labeled green, and nuclei blue (DAPI). Figure shows merged images. Scale bars = 100 μm. g Immunoblot analysis of AR, and AHR in tumor specimens.

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