Fig. 2: ALOXE3 deficiency promotes orthotopic GBM growth and shortens lifespan in mice. | Oncogenesis

Fig. 2: ALOXE3 deficiency promotes orthotopic GBM growth and shortens lifespan in mice.

From: miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities

Fig. 2

A Relative mRNA level of ALOXE3 normalized with GAPDH in shALOXE3-U87 and shCont-U87 cells (n = 6). B Immunoblotting analysis of ALOXE3 and GAPDH in shALOXE3-U87 and shCont-U87 cells. Representative immunoblot images are shown (n = 6). C–E shALOXE3-U87 and shCont-U87 cells were implanted orthotopically into the hippocampus of immunodificient nude mice (n = 6). C In vivo bioluminescent imaging of nude mice at indicated time points. The right panel is the quantification of luminescence signal intensity. D Body weight of mice. All data are represented as the mean ± s.e.m. *p < 0.05 (Student’s t-test). E Survival curve of mice. Medians are shown. *p < 0.05 (Long-rank test).

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