Fig. 6: Chemotherapeutic treatment in orthotopic and syngeneic gall bladder (GB) cancer model. | Oncogenesis

Fig. 6: Chemotherapeutic treatment in orthotopic and syngeneic gall bladder (GB) cancer model.

From: Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds

Fig. 6

A A scheme of chemotherapeutic treatment. TVM tumor volume measurement. An inspected tumor is shown (open arrowhead). B The tumor volumes in vehicle- (n = 10) or gemcitabine-treated groups (n = 10) on day 14 and 42 after IoTB. N.S., not significant. *p < 0.0001. c Macroscopic findings of the treated tumors. Representative images are shown. T tumor, L liver. Dashed lines (upper panel) indicate the cut surface of the tumors (lower panel). Scale bar, 5 mm. D Microscopic features of the tumors. Representative images of hematoxylin and eosin (H&E) staining are shown. Upper panel, whole images of the tumors. Scale bar, 1 mm. Lower panel, invasion front adjacent to the liver. Scale bar, 0.1 mm. E The proportion of Ki-67+ proliferating cells among CK19+ epithelial cells in each group. Left, representative images of immunostaining. Cell proliferation (red, Ki-67), epithelial cells (green, CK19), and the nucleus (blue, DAPI) are visible. Scale bar, 50 μm. Right, summary of the results. *p = 0.036.

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