Fig. 1: NMI and STAT5A show concurrent expression pattern during mammary gland differentiation.
From: Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors
a NMI and STAT5A expression within computational reconstruction of the luminal compartment generated from single-cell RNA-seq mouse mammary cells different stages of differentiation. b t-distributed stochastic neighbor embedding (t-SNE) overlaid NMI and STAT5A expression in different Luminal and Basal clusters. c Immunohistochemical staining for STAT5A and NMI on mouse mammary tissues during different stages of development (puberty, mature non parous, pregnancy d10.5, pregnancy d14.5, lactation d1, lactation d4, involution d1, involution d3, and involution d8). d IHC immunoscore for STAT5A and NMI staining on mouse mammary tissues during differentiation. Expression was the highest during pregnancy and lactation, then subsided during the course of involution. The pattern of expression showed a significant positive correlation between NMI and STAT5A.
