Fig. 7: Schematic summary of findings.
From: Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors
In normal breast NMI and STAT5A signaling keeps ISG20 expression in check, through expression of miR-20a and cells undergo normal differentiation. In cancer, NMI and Stat5A expression is compromised that reduces the check on ISG20 expression. Increased ISG20 promotes invasive progression that leads to metastatic colonization at a secondary site.
