Fig. 2: CtBP1/2 knockdown impacted cell cycle of ovarian cancer cells. | Oncogenesis

Fig. 2: CtBP1/2 knockdown impacted cell cycle of ovarian cancer cells.

From: CtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell

Fig. 2

The enrichment plot of cell cycle-related genes was identified by GSEA in CtBP1 KD (left) and CtBP2 KD (right), compared to control cells (A). Heat maps significantly comparing the expression of genes that involved in cell cycle regulation in CtBP1/2 KD and control groups (B). The comparison between CtBP1/2 KD and control groups in cell cycle by flow cytometry (C, D). The cell cycle profile also was created by measuring total DNA content with PI. Data were representing each phase of cell cycle and quantitative analysis the percentage generated by three independent experiments. Western blot analyzed the changed pattern of cell cycle key regulators between CtBP1/2 knockdown and control (E). All the data represented the average of triplicates values generated by three independent experiments. *P < 0.05; **P < 0.001; ***P < 0.0001.

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