Table 1 The histogram comparison of IdU/CIdU labeled track among different groups.

From: CtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell

Group

Ctrl

CtBP1 KD

CtBP2 KD

(A)

Fiber labeled

IdU

IdU

IdU

Hu treatment

No

No

No

Total number of values

463

486

564

Number of excluded values

0

0

0

Number of binned values

463

486

564

Minimum

1.4789

0.4921

1.1241

25% Percentile

3.9083

1.3416

3.5703

Median

7.0396

1.7793

5.3212

75% Percentile

12.4812

2.6548

8.5748

Maximum

152.3000

17.0759

46.5034

Mean

10.1338

2.3528

7.1760

Std. deviation

10.7540

1.9222

5.6054

Std. error

0.4998

0.0872

0.2360

Lower 95% CI of mean

9.1516

2.1815

6.7123

Upper 95% CI of mean

11.1159

2.5241

7.6396

P value (compared with control)

 

<0.0001

<0.0001

Exact or approximate P value?

 

Gaussian approximation

Gaussian approximation

P value summary

 

***

***

Are medians signif. different? (P < 0.05)

 

Yes

Yes

One- or two-tailed P value?

 

Two-tailed

Two-tailed

Sum of ranks in columns

 

314700, 136100

261572, 266306

Mann–Whitney U test

 

17760

107000

(B)

Fiber labeled

IdU

IdU

IdU

Hu treatment

HU

HU

HU

Total number of values

368

467

323

Number of excluded values

0

0

0

Number of binned values

368

467

323

Minimum

0.8832

0.4403

0.4921

25% Percentile

2.9681

1.1888

2.6470

Median

4.5338

1.5592

4.2139

75% Percentile

7.2494

2.1730

6.6304

Maximum

58.7360

8.4071

24.1647

Mean

5.9196

1.7409

5.2163

Std. deviation

5.2803

0.9031

3.5468

Std. error

0.2753

0.0418

0.1973

Lower 95% CI of mean

5.3783

1.6588

4.8281

Upper 95% CI of mean

6.4609

1.8230

5.6046

P value (compared with control)

 

P < 0.0001

P = 0.083

Exact or approximate P value?

 

Gaussian approximation

Gaussian approximation

P value summary

 

***

ns

Are medians signif. different? (P < 0.05)

 

Yes

No

One- or two-tailed P value?

 

Two-tailed

Two-tailed

Sum of ranks in columns

 

227800, 121300

131900, 107200

Mann–Whitney U test

 

11990

54890

(C)

Fiber labeled

CIDU

CIDU

CIDU

Hu treatment

No

No

No

Total number of values

464

550

607

Number of excluded values

0

0

0

Number of binned values

464

550

607

Minimum

0.3522

0.2202

0.3108

25% Percentile

2.0927

0.9350

1.2484

Median

3.1818

1.2872

1.7793

75% Percentile

5.2940

1.8726

2.7273

Maximum

21.2328

12.8050

14.7241

Mean

4.0334

1.6641

2.2644

Std. deviation

2.8261

1.3866

1.6607

Std. error

0.1312

0.0591

0.0674

Lower 95% CI of mean

3.7756

1.5480

2.1320

Upper 95% CI of mean

4.2912

1.7803

2.3968

P value (compared with control)

 

P < 0.0001

P < 0.0001

Exact or approximate P value?

 

Gaussian approximation

Gaussian approximation

P value summary

 

***

***

Are medians signif. different? (P < 0.05)

 

Yes

Yes

One- or two-tailed P value?

 

Two-tailed

Two-tailed

Sum of ranks in columns

 

324900, 189700

316700, 257300

Mann–Whitney U test

 

38170

72790

(D)

Fiber labeled

CIDU

CIDU

CIDU

Hu treatment

HU

HU

HU

Total number of values

389

466

382

Number of excluded values

0

0

0

Number of binned values

389

466

382

Minimum

0.4403

0.2202

0.3108

25% Percentile

0.9868

0.8832

0.8832

Median

1.2872

1.1033

1.1033

75% Percentile

1.7793

1.4116

1.3416

Maximum

27.7933

3.1572

5.0790

Mean

1.7474

1.1733

1.1504

Std. Deviation

1.9343

0.4441

0.5018

Std. Error

0.0981

0.0206

0.0257

Lower 95% CI of mean

1.5546

1.1329

1.0999

Upper 95% CI of mean

1.9402

1.2138

1.2009

P value (compared with control)

 

P < 0.0001

P < 0.0001

Exact or approximate P value?

 

Gaussian approximation

Gaussian approximation

P value summary

 

***

***

Are medians signif. different? (P < 0.05)

 

Yes

Yes

One- or two-tailed P value?

 

Two-tailed

Two-tailed

Sum of ranks in columns

 

190448, 175492

172800, 124800

Mann–Whitney U test

 

66680

51610

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