Fig. 3: BTK regulates invasive phenotypes via the JAK2/STAT3 pathway in NSCLC cells. | Oncogenesis

Fig. 3: BTK regulates invasive phenotypes via the JAK2/STAT3 pathway in NSCLC cells.

From: Bruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma

Fig. 3

A Immunofluorescence study showed the level of SOX-2 and p-STAT3 were parallel in PC-9 cells with different status of BTK. Scale bar 50 μm. B p-STAT3 expression was upregulated in BTKpos cells derived from both A549 and PC-9 cells. C Expression of p-STAT3, p-JAK2, p-Akt, and ITK in BTKpos PC-9 cells were suppressed by Acalabrutinib in a time-dependent manner. Effect of Acalabrutinib on D cell migration (scale bar 20 μm), E colony formation, and F sphere formation (scale bar 50 μm) in BTKpos A549 and PC-9 cells are present. CTL control. *p < 0.05, **p < 0.01.

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