Fig. 5: BTK inhibitor Acalabrutinib induces apoptosis in A549 (EGFR wild type), H1975 (EGFR T790M), and PC-9 (mutant EGFR with 19 Del) cells. | Oncogenesis

Fig. 5: BTK inhibitor Acalabrutinib induces apoptosis in A549 (EGFR wild type), H1975 (EGFR T790M), and PC-9 (mutant EGFR with 19 Del) cells.

From: Bruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma

Fig. 5

A Effects of Acalabrutinib on apoptosis induction after treatment of Acalabrutinib at the indicated concentrations for 48 h. Apoptosis was determined by the annexin-V/PI assay. Bars represent mean ± SD. *p < 0.05, **p < 0.01. B Modulation of Acalabrutinib on apoptotic proteins in Gefitinib-resistant H1975 cells.

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