Fig. 1: ESRP1 is upregulated in primary breast tumors and is associated with a poor prognosis. | Oncogenesis

Fig. 1: ESRP1 is upregulated in primary breast tumors and is associated with a poor prognosis.

From: E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression

Fig. 1

A TCGA gene expression profile of ESRP1 pertaining to normal breast tissue and primary breast tumor obtained from the UALCAN platform (P = 1E–12). and B immunoblot of ESRP1 in normal versus breast cancer tissue (n = 4). Furthermore, refer to Supplementary Fig. S1B for more samples. C Kaplan–Meier Plot for relapse free survival of breast cancer patient comparing the upper (red) and lower (black) quartile ESRP1 expression (Affy ID 225846_at) obtained from www.kmplot.com (Logrank P = 9E–14), Hazard ratio = 2.39 (1.89–3.03). D Schematic representation of human ESRP1 promoter analysis in MCF-7 cells. Numbers indicate the position of primers. +1 indicates transcription start site. Deletion constructs of different ESRP1 promoters and their luciferase activities are shown. E Nucleotide sequence alignment of the proximal promoters of orangutan, human, chimpanzee, rat, and mouse ESRP1gene. Putative E2F1 binding site is underlined. Numbers indicate the position of nucleotide sequence corresponding to the human ESRP1 promoter.

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