Fig. 5: iP300w suppresses the CIC-DUX4 target transcriptome. | Oncogenesis

Fig. 5: iP300w suppresses the CIC-DUX4 target transcriptome.

From: Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma

Fig. 5

A Scatter plots of −log10 fold change of the Benjamini–Hochberg adjusted p-value versus the observed log2 fold change in gene expression. The changes with 4 and 24 h of iP300w treatment are shown on the left and right, respectively. The y-axis in each plot has been expanded in the lower panels relative to the upper panels. Points colored in red correspond to the 165 transcripts upregulated by CIC-DUX4 as previously reported [16]. B Heatmap of the log2 padded FPKM values of CIC-DUX4 targets from Okimoto et al. [16] in NCC-CDS1-X1 cells upon treatment with iP300w. C Enriched KEGG pathways (hypergeometric test, Benjamini–Hochberg adjusted p-value < 0.05) of the differentially expressed genes at 4 h (left) and 24 h (lower right). The x-axis corresponds to the log10 adjusted p-value such that downregulated genes are shown on the negative axis (blue) and upregulated genes (orange) are shown on the positive axis in each plot.

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