Fig. 5: Cdk5 upregulates cancer-related pathways.
From: Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors
A Heatmap of differentially expressed genes in normal mouse islets (NI1–3), functional (M1–3) and non-functional (M4–6) INS-p25OE PanNETs. B Principal component analysis of expression data. C Volcano plot of annotated genes upregulated and downregulated in INS-p25OE tumors (all 6) compared to normal mouse islets; fold change (FC). D Table of differentially expressed genes that overlap with alterations in human PanNETs; gene amplification (GA), overexpression (OE), decreased expression (DE). E Ingenuity Pathway Analysis of genes differentially expressed between INS-p25OE tumors (all 6) and normal islets. Pathways are related to cell cycle (red), DNA repair (blue), vascularization (green), and extracellular matrix (black).
