Fig. 1: CCND3 exceeds expression of CCND1 and CCND2 at mRNA and protein levels in B-ALL.
From: CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia
A The mRNA expression data of CCND1, CCND2, and CCND3 in different B-ALL subtypes were mined from publicly available databases using the GENEVESTIGATOR software (http://www.genevestigator.com/). The experiment IDs are listed in Supplementary Materials and Methods. Data shown as mean ± SD. B The mRNA expression levels of D-type cyclins in B–ALL (blue) and control cell lines was measured by qRT-PCR. The control cell lines included Burkitt lymphoma (Ramos), cHL (L428), and HEK293T which express high levels of CCND3, CCND2, and CCND1, respectively. Data shown as mean ± SD, n = 3. C Ratio of mRNA levels CCND3/CCND2 measured by qRT-PCR in B-ALL cell lines. D Expression of CCND2 and CCND3 proteins in B-ALL cell lines was measured by immunoblot. TUBB is used as loading control. Image representative of n = 3.
