Fig. 1: PTEN regulates GNMT expression.
From: PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
A Gnmt mRNA expression in Ptenpc−/− and Ptenpc+/+ prostate tissue from 6-month-old mice (n = 3). B GNMT expression in PCa patient specimens with diploid or homozygous deletion of PTEN in two different datasets. Data was retrieved from www.cbioportal.org. C GNMT mRNA expression upon treatment (24 h) with Vehicle (Veh, DMSO), BKM120 (BKM, 5 µM) and MK2206 (MK, 500 nM) in PC3 and LnCaP cells (n = 3). Data are represented as mean with SEM (A, C) and violin plot (B). Statistic test: Student T-test (A); Mann–Whitney U-test (B) and One sample T-test (C). p, p value; *p < 0.05; **p < 0.01; ***p < 0.001.
