Fig. 8: KSR1 overexpression restores the induction of autophagy and inhibition of the MEK1/ERK/mTOR signaling pathway by AOS-SO4 treatment. | Oncogenesis

Fig. 8: KSR1 overexpression restores the induction of autophagy and inhibition of the MEK1/ERK/mTOR signaling pathway by AOS-SO4 treatment.

From: Sulfated alginate oligosaccharide exerts antitumor activity and autophagy induction by inactivating MEK1/ERK/mTOR signaling in a KSR1-dependent manner in osteosarcoma

Fig. 8

A Osteosarcoma cells were treated with AOS-SO4 for 48 h with or without transfection with HA-KSR1, and LC3 puncta were analyzed by the mRFP-GFP-LC3 construct. B Autophagosome-like structures (indicated by the yellow arrows) were assayed by TEM. C Protein levels of proliferation, apoptosis, autophagy, and KSR1, MEK1, and p-ERK in cells treated with AOS-SO4 for 48 h with or without transfection with the HA-KSR1 plasmid. Data are shown as the means ± SD from at least three independent experiments.

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