Fig. 6: The ZDHHC4–GSK3β–STAT3 axis was correlated with the malignant degree of human glioma. | Oncogenesis

Fig. 6: The ZDHHC4–GSK3β–STAT3 axis was correlated with the malignant degree of human glioma.

From: GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis

Fig. 6

A Differences in ZDHHC4 expression in tumors and normal tissues of various organs obtained from the GENT database. B Relationship of ZDHHC4 to glioma grade from the REMBRANDT database. C, D Diagram of ZDHHC4 expression with overall survival and disease-free survival in glioma patients obtained from TCGA database. E Immunohistochemical staining showed that ZDHHC4 expression was correlated with p-GSK3β (Y216), p-STAT3 (Y705), and MGMT; 125 biologically independent samples were analyzed. The red dotted line marks the area corresponding to the high magnification image. F Statistical analysis of the Pearson correlation between the immunohistochemical staining score of ZDHHC4 expression and p-GSK3β (Y216) or p-STAT3 (Y705) expression.

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