Fig. 7: Schematic showing that ZDHHC4-mediated GSK3β palmitoylation promotes GBM TMZ-resistance. | Oncogenesis

Fig. 7: Schematic showing that ZDHHC4-mediated GSK3β palmitoylation promotes GBM TMZ-resistance.

From: GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis

Fig. 7

ZDHHC4 palmitoylates GSK3β and competitively binds GSK3β with AKT and p70S6K kinases, which inhibits GSK3β Ser9 phosphorylation and enhances GSK3β Tyr216 phosphorylation. Activated GSK3β enhances GSC self-renewal, GBM TMZ-resistance, and tumorigenesis by promoting the EZH2/STAT3 axis.

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