Fig. 3: Overexpression of USP53 inhibited HCC xenograft growth in vivo.
From: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c
A Tumor growth kinetics curve of oe-USP53 group and control. n = 5. B Tumors obtained from nude mice that implanted with oe-USP53 HCCLM3 cells (n = 5) and control HCCLM3 cells (n = 5). C Tumor volume in the control and USP53-overexpression groups. n = 5. D, E PET-CT images of orthotopic HCC xenografts in the indicated groups. n = 3. F Representative images showing the in-situ expression of USP53 in three pairs of xenograft tissues. Magnification 100x and 400x. G Representative images showing the in-situ expression of Ki-67 in the tumor xenografts of NC group and USP53-overexpression groups. Magnification 100x and 400x. H, I Representative images showing TUNEL + cells in the indicated xenografts. Magnification 400x. All experiments were repeated three times. *p < 0.05; **p < 0.01; ***p < 0.001.
